Job Description
We are looking for a Research Assistant in bioinformatics with experience in single-cell computational methods and immunology. The Research Assistant will be a junior team member with a First or Master’s degree in a related subject (e.g. computer science, bioinformatics, life sciences) and will join Prof. Christina Zielinski’s group to unravel how the regulation of human tissue resident T cells across organs and to decode their tissue specific functions.
Using multimodal state-of-the-art single-cell technologies (scRNAseq, TCR-seq, CITE-seq), high-dimensional flow cytometry and other high-throughput cell culture technologies for the analysis of human tissues from multi-organ donors and from patients after allogeneic stem cell transplantation, we have generated data sets for our ERC-funded project ORGANise-T to leverage the dynamics by which different T cell types (etc. CD8, CD4, gd T cells, MAIT cells) adapt to distinct tissue microenvironments and compartmentalize across the human body (function, TCR-repertoires). The candidate will have the possibility to analyze additional transcriptomic data sets related to the regulation of T cells in health and disease in collaboration with other team members and external partners.
Overall, ORGANise-T will establish first-of-its-kind insights into the spatio-temporal dynamic organisation of human T cell immunity in tissues. This will bring the next generation of immunotherapies to the level of tissue selectivity.
The post is a unique opportunity for an enthusiastic computational scientist or an immunologist with solid bioinformatic skills (coding, Seurat and Scanpy pipeline usage) with an aptitude for semi-independent work. It provides multiple opportunities for collaboration on other single-cell genomic projects. The research assistant position might also allow transition to a PhD position.
The ability to work both independently and as part of a team, coupled with excellent communication, organizational and problem-solving skills is required. Other duties/responsibilities include contributing to research and publications and writing up own research
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.
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